Endocrine Abstracts

Graves’ disease (GD) is an autoimmune disease with genetic predisposition. The link with the major histocompatibility complex determines the complexity of the excess thyroid hormones molecular action on immune system that may cause the divergence of autoimmune process in GD, functioning not only in peripheral immune cells, but also in the thyroid. Objective: to study the phenotypic composition of T- and B-lymphocyte subset patterns in peripheral blood and thyroid tissue i...

Background: Foxp3(+) regulatory T cells (Treg) play a leading role in developing immune tolerance through active suppression in Graves’ disease (GD). The influence of radioactive iodine therapy (RAI) on the differentiated fractions of Treg of GD patients is still poorly understood. Aim: To estimate the differentiated fractions of blood Tregs and the CD25 expression in patients with GD after RAI.Materials and Methods: In total,...